Drummond Scientific has a long and outstanding history in the manufacturing of microinjection apparatus. Several years ago we became aware that our 10uL positive displacement microdispenser was being modified to inject Xenopus oocytes. We modified this unit by redesigning the microdispenser to eliminate any tip movement caused by plunger rotation.
Further modifications seemed uneconomical which prompted a complete redesign. Drummond developed a positive displacement motorized unit which was capable of repetitively dispensing precisely 46 nL., a volume optimized for oocyte injection. This was to be the first Nanoject.
The next model offered the scientist a variable volume, ranging from 4.6 nL. to 73.6 nL. Hence, the Nanoject Variable.
The introduction of the Nanoject II offers volumes ranging down to 2.3 nL. and up to 69nL. with a higher torque motor. This new motor is quieter and smoother in operation further reducing tip movement. The development of new collet configuration will hold the micropipet more securely and thereby reduce air infiltration and oil leakage. The two speed fill/inject mode will allow the user to fill and inject at half speed facilitating the use of smaller micropipets. The handling of more viscous samples will also be improved. All factors which enhance the precise delivery of sample.
Although previous models are excellent for Xenopus injections, the smaller tips and smaller injection volume may allow the user to perform injections into other specimens that previously could not be performed with older models.
Positive displacement technology and the use of precision micropipets, eliminates the need for tedious calibration when the viscosity of the samples change. Contaminates in the sample do not hinder or change the injection volume as with some other injectors.
The Drummond Nanoject II Auto-Nanoliter Injector is specifically designed to perform ultra-delicate nanoliter injection procedures into cells. Each Nanoject II Auto-Nanoliter Injector comes complete with 200 borosilicate capillaries that can be pulled to the required tolerance together with a back filling needle and maintenance kit.
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